Abstract
Intensity-modulated radiotherapy (IMRT) is now commonly utilized to treat prostate cancer. While the improved penumbra of intensity-modulated fields allows for tighter margins and reduced dose to normal tissues, the margins used in generating a planning treatment volume (PTV) to ensure adequate coverage of the clinical target volume (CTV) must also take into account patient set-up uncertainty and organ motion. There must be a limit to how small margins can be set to ensure adequate coverage of the CTV.
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