(274) Phospholipase A2 of Macrovipera lebetina obtusa venom as a main target to relief pain after snake bites

Abstract

Snake venoms are complex mixture of proteins and peptides, which comprise about 90-95 % of venom dry weight and other minor components (e.g. ions, carbohydrates, amines etc.). The majority of damages on victims’ organism are caused by viper venoms’ metalloproteinases, serine proteases and phospholipase A2 (svPLA2). Besides heavy damages, snake bites may also cause strong pain sensations. Particularly, pain syndrome is characteristic for the bites of Levantine viper. The main aim of this study was to reveal the mechanism of Macrovipera lebetina obtusa (MLO) venom’s nociceptive action.