Abstract
The aim of the study was the evaluation of parenteral symptoms and complications incidence in children with non-specific colitis and their analysis in relation to the mutations of CARD15 gene. Patients and methods: The study involved 38 children with Crohn's disease, aged from 5 to18 years and 40 children with ulcerative colitis, aged from 6 to 18 years. The control group included 23 children, aged from 4 to 18 years, with functional disorders of the alimentary tract resulting from lactose intolerance. In all the examined patients mutations R702W, G908R and L1007fs of CARD15 gene were determined, according to the protocol described by Tukel. Results: Parenteral symptoms in the group of children with Crohn's disease, manifested as arthritis and erythema nodosum, were observed in 7 patients (18.4%), whereas in the group with ulcerative colitis- in 4 children (10%). Intestinal complications in the form of stenosis, fistula, abscess and gastrointestinal bleeding were the most frequently observed in children with Crohn's disease 15 (39.5%) Parenteral symptoms were statistically significantly more frequent in children with Crohn's disease and at least one mutation of CARD15 gene. Intestinal complications statistically appeared more often in children with Crohn's disease and mutation L1007fs. Conclusions:
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
