273 Influenza vaccination in CF adults: Coverage level and adverse reactions

Abstract

Objectives Influenza increases morbidity in CF individuals. Annual vaccination against influenza is a recommended measure in people with chronic respiratory diseases including CF. However, there are worries about adverse reactions of influenza vaccine in some patients and coverage level is generally low in the Czech Republic (approximately 5% of population). Methods We conducted a study in CF adults in Prague CF Centre regarding to coverage level and occurrence of adverse reactions after influenza vaccination using interviews during visits of CF clinic or by phone or e-mail in January 2015. Results 112 CF adults (59 males) with mean±SD age 27.3±6.2 years and mean±SD FEV 1 68±26 pred. were interviewed. Thirty-two (28.6%) patients received influenza vaccine. Among them, three patients experienced adverse reaction of mild intensity. In those who did not received a vaccination, eleven subjects reported adverse reactions in the past (two of them described it as severe), four patients experienced prolonged pulmonary exacerbations and others (58.0% of study group) had no interest in vaccination. Together, current or previous adverse reactions were reported in 14 (12.5%) subjects. Level of vaccination was not associated with sex, age or lung function. Conclusion Coverage level of influenza vaccination in Czech CF adults is low. The main reason is no interest for vaccination. Adverse reactions were quite frequent but usually with only mild intensity.