273 Does insulin treatment influence growth and lung function in children with abnormal oral glucose tolerance test (OGTT) but normal fasting glucose?

Abstract

Aims: To study the influence of insulin treatment on growth and lung function in children with CF who had an abnormal OGTT but normal fasting glucose. Methods: The study included CF patients who had an abnormal OGTT (2 h glucose >7.8retool/i) but normal fasting glucose: 14 given insulin glargine (Gp A) owing to clinical deterioration and 13 not given insulin (Gp B). They were compared to 55 CF patients with normal OGTT (NGT). Height (Ht), weight (Wt) and BMI (expressed as SDS), and best FEV1% at diagnosis and treatment (tO), and changes in the 12too before (Awe) and 12mo after (Apost) were compared. Median values shown and nonparametric analysis taking account of repeated measures used. Results: Gp A differed from B in the following: higher 2 h plasma glucose (11.9 vs 9.5 retool/l, P 0.01) and significant decline in Wt in preceding 12 mo (P 0.02). Gp A had lowest Wt tO and BMI tO ( 0.6 SDS; B: 0.1 SDS; NGT: 0.3 SDS). Compared to NGT, gp A and B had lower Ht tO (P 0.03), FEV1 tO (P 5%) before tO in 8/14 gp A patients and improved in 6 of these. It declined in 7/13 gp B patients and improved in 5 of these.