Abstract
TALA is a poly (ADP-ribose) polymerase inhibitor approved in the US, EU, and other countries for the treatment of deleterious/suspected deleterious gBRCA1/2mut HER2-negative ABC. While TALA treatment in the phase 3 EMBRACA trial (NCT01945775) benefited pts regardless of PP, greater improvements in clinical outcomes for TALA vs PCT (capecitabine, eribulin, gemcitabine, or vinorelbine) were seen for pts not treated with PP (PFS hazard ratio [95% CI] 0.76 [0.40–1.45], P = 0.41 for PP vs 0.52 [0.39–0.71], P < 0.0001 for no-PP subgroups).
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