Abstract
Umbilical cord tissue or Wharton's Jelly is a rich source of rapidly proliferating mesenchymal stromal cells (human cord tissue MSCs; hCTMSC) that can be cultured on a large-scale. We are developing this MSC product for use in the treatment of children with autism spectrum disorders (ASDs) where increasing evidence points to a central role for immune dysregulation involving abnormal activation of microglial cells. We developed an organotypic brain slice culture model to ask whether hCTMSC inhibit microglial activation in vitro. We plan to use the assay to explore whether it could serve as a biomarker to predict the potential therapeutic effectiveness of various lots of MSCs in patients with ASDs.
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