Abstract
Background: Hepsin, a type II transmembrane serine protease encoded by HPN gene, is commonly overexpressed in prostate and breast cancer. Hepsin protein is stabilized by Ras-MAPK pathway signaling, and downstream, this protease regulates the degradation of extracellular matrix components and activates growth factor pathways, including hepatocyte growth factor and transforming growth factor (TGF) beta pathway. The significance of the hepsin-dependent signaling on cell proliferation and tumor growth is still partially unclear.
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