Abstract
The accumulation of senescent cells is associated with several age-related pathologies and represents a primary driver of skin aging. Senescence cells cause tissue damage by secreting a mix of pro-inflammatory cytokines and extracellular matrix remodeling factors. This study aims to elucidate how ribosomes and protein translation change in cellular senescence. Particularly we focus on alterations of the methylation patterns of ribosomal RNA. We exposed human dermal fibroblasts to doxorubicin to induce cellular senescence and tested if specific methylations of ribosomal RNA contribute to the senescent phenotype.
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