Abstract
Chronic low back pain (cLBP) has been associated with maladaptive brain plasticity, and non-pharmacological therapies such as Spinal Manipulative Therapy (SMT) have shown promise in reducing pain and modifying intrinsic brain physiology. However, more translational research is needed using clinical models. We investigated functional salience network (SLN) connectivity response to SMT, and linked response to cLBP pain reduction. Fifteen cLBP patients (8 female, 37.7 ± 9.7 (M± SD) years old), and 16 healthy controls (HC, 8 female, 38.2 ± 10.4 years old) were scanned with resting state fMRI before and after a single session of spinal manipulation and spinal mobilization (grades V and III of the Maitland Joint Mobilization Grading Scale) at separate visits. Patients rated clinical pain (0-100) pre- and post-therapy. Intrinsic SLN connectivity was assessed using dual regression probabilistic independent component analysis. Voxelwise analyses were cluster corrected for multiple comparison (z>2.3, p
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