27. Deregulation and shattering of chromosomal segments containing multiple oncogenic targets in the pathogenesis of diffuse large B cell lymphoma (DLBCL)

Abstract

Chromoanasynthesis involves massive chromosomal rearrangements arising during single chaotic cellular events. Reconstitution of the extensive abnormalities may result in focused duplication, triplication and deletions, gene fusions, amplification, loss of tumor suppressor genes and marker chromosomes. We report a case of a 27-year-old male with a prior history of relapsed Hodgkin lymphoma (in 2010), treated with chemoradiotherapy and autologous stem cell transplant, who presented in February 2021 with diffuse large B cell lymphoma (DLBCL), germinal center type, involving bone, bone marrow, lymph nodes, nasopharynx, kidney, and spleen. Chromosome analysis of the biopsy was highly complex with multiple structural and numerical abnormalities and marker chromosomes.