Abstract
The cause of prepubertal hypertrichosis (H) is unknown. Plasmatic androgen levels were determined in 17 girls with H, (ca: X±SD: 5.5±1.41 years), 11 girls with precocious pubarche (PP) and 9 normal prepubertal girls (CP). All of them were assesed according to their distribution score of vellus hair. Group H. was characterized by excessive growth of vellus hair (score>7), CP showed normal distribution and PP group had pubic hair II-III without excessive growth of vellus hair (score<5)17OH Progesterone, Androstenedione (A), DHEA-S, Testosterone (T), SHBG and 3 Androstanediol glucoronide(3 AG)were measured by RIA. Normal levels of A and DHEA-S and elevated 3 AG levels suggest an increase in the peripheral activity of 5 reductase in most prepubertal girls with hypertrichosis.
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