269: Antimicrobial Activity of Novel S-(benzyl) Isothiourea Derivatives Against Multiply Resistant Pseudomonas aeruginosa and Burkholderia cepacia Complex from Patients with Cystic Fibrosis Undergoing Lung Transplant Assessment

Abstract

In patients with cystic fibrosis (CF), strains of Pseudomonas aeruginosa and Burkholderia cepacia complex (BCC) are regularly found to colonize the lungs, leading to extensive morbidity and mortality. Such strains frequently display resistance to most, if not all, commonly used antimicrobials and there is a pressing need to identify new agents. In 2004, Iwai et al. Described a novel group of antimicrobials based on S-(benzyl) isothiourea that attacked the actin-like cytoskeletal protein MreB in rod shaped bacteria.