#2667 CARDIOVASCULAR AND MORTALITY RISKS IN YOUNG HEALTH SCREENING EXAMINEES WITH MARGINAL ESTIMATED GLOMERULAR FILTRATION RATE

Abstract

Abstract Background and Aims Additional evidence is necessary to interpret the kidney function parameters in young adults, particularly in those with marginal eGFR values. We aimed to study the clinical significance of marginal eGFR values in large-scale general health screening examinees of young age (20-39 years). Method We performed a nationwide retrospective cohort study using the health screening database of South Korea. We included young adults aged 20-39 years without a history of major cardiovascular events (MACE) or end-stage kidney disease who underwent a nationwide health screening in 2012. The study exposure was eGFR categorized into 15 mL/min/1.73 m2 intervals, with a reference group and a main group of interest: < 30, 30-45, 45-60, 60-75, 75-90 (reference), 90-105, 105-120, and ≥ 120 mL/min/1.73 m2. The risks of all-cause mortality and MACE were calculated using Cox regression analysis adjusted for various clinicodemographic characteristics. Results In total, 3,132,409 young adults were included in this study. During a median follow-up of 7.3 years, marginal eGFR (60-75 mL/min/1.73 m2) was not significantly associated with a higher risk of all-cause mortality [adjusted HR 0.92 (0.86-0.99)]. The results were similarly identified for the MACE outcome [adjusted HR 1.01 (0.94-1.07)]. On the other hand, those with presence of albuminuria, even the marginal eGFR range was significantly associated with higher risks of all-cause mortality [adjusted HR 1.52 (1.01-1.29)] and ischemic stroke [adjusted HR 1.73 (1.10-2.74)]. Conclusion Marginal eGFR alone was not associated with higher risks of all-cause mortality and MACE in general young adults. However, in those with albuminuria, the mortality risk was higher even in eGFR of 60-75 mL/min/1.73 m2.