265P - Breast Cancer in Young Women in India

Abstract

ABSTRACT Background The incidence of breast cancer is rising in India. It presents at a younger age in Indian population as compared to the western countries. Aims and objectives: This is a retrospective study of all breast cancer patients less than 40 years of age treated in single tertiary care center from June 2006 to June 2011. The aim was to assess the factors that may influence clinical outcome and prognosis including demographics, clinical characteristics and pathological findings and treatment. Materials and methods Clinical data was collected from medical records. Variables like age, stage at presentation, surgery type, chemotherapy, radiation, tumour size, grade, nodal status, perinodal extension, lymphovascular emboli, ER, PR and Her2 neu status were analyzed in relation to outcome. Results Out of 613 breast cancer patients, 91 were under 40 years of age corresponding to an incidence of 14.8%. Median tumour size was 3 cm and lymph node positivity was 56.9%. Lymphovascular emboli was positive in 42 patients (48.8%) and perinodal extension was positive in 36 patients (41.8%). Thirty patients (34.8%) were ER positive, while 39 patients (45.3%) were PR positive. Her 2 neu receptors were positive in 20 patients (23.2%). Thirty nine patients were triple negative (45.3%). The median follow up period was 27 months with the DFS being 73.2% and OS being 87.2%. In univariate analysis, factors significantly associated with survival were stage at presentation, presence of lymhovascular emboli, presence of perinodal extension and grade of the tumour. Conclusions Breast cancer in India is seen in younger patients and most of these are triple negative breast cancers. Patients with breast cancer below 30 years of age are surviving more than the age group of 30 to 40 years. Survival of young breast cancer patients in India is comparable to western studies. Disclosure All authors have declared no conflicts of interest.