Abstract
Oncogene activation not only plays a major role in tumor development and progression, but is also an important determinant in the response of tumor cells to anticancer therapies. Consistent with this notion, in head and neck squamous cell carcinomas (HNSCC), aberrant expression or activation of EGFR and of NF-κB signaling has been implicated not only in tumor development but also in chemo- and/or radiation resistance. In this study we used immortalized but non-tumorigenic human keratinocytes (HaCaT cells) over-expressing EGFR (HaCaTEGFR) and NF-κBp65 (HaCaTp65), respectively, to study the function of aberrant EGFR and NF-κB signaling in epithelial tumor development and radiation resistance.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: International Journal of Radiation Oncology*Biology*Physics
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
