264 Diastolic dysfunction in pediatric renal transplant patients

Abstract

Eur J Echocardiography Abstracts Supplement, December 2006 and if there were records of the left ventricular inflow by Doppler. Restrictive pattern was defined as E/A >1.5 and E-wave deceleraration time (DTE) 150 ms being pseudonormal if there was left atrium dilation. Results: Echocardiograms of 535 patients were studied, 78% male, aged 64±14. Normal pattern was present in 84 patients (16%), 65 (12%) had abnormal relaxation, 257 (48%) had a pseudonormal pattern and 129 (24%) had restrictive filling pattern. Coronary heart disease was more prevalent in the abnormal relaxation group than in the pseudonormal group (p=0.03). Patients with a restrictive pattern had a higher probability of being hospitalized than those with normal (p=0.001) and pseudonormal patterns (p=0.006). They had higher LVEDV (p=0.0007) and LV end-systolic volume (p<0.0001), lower LV fractional shortening fraction (p<0.0001), higher right ventricle enddiastolic volume (p<0.0001) and bigger left and right atrium dimensions (p<0.0001). A multiple linear regression model (R2=0.114; p<0.0001) determined that right ventricular end-diastolic volume (p=0.0007) was the only independent predictor of DTE. Conclusions: In DCM patients a restrictive filling pattern in a common finding especially in hospitalized patients. It relates to worse LV systolic function and to findings that may traduce higher filling pressures. Right ventricle dimension was the best predictor of the low DTE that characterizes restrictive filling pattern. This finding brings the focus on the possible role of ventricular interaction as a contribution to worse filling of the left ventricle in DCM.