263: Twin pregnancies with different gender are related with adverse neonatal outcomes in dichorionic twins kyung

Abstract

ObjectiveThe purpose of this study was to evaluate whether neonatal outcomes are different between newborns of same gender and those of different gender in dichorionic twins.Study designWe studied consecutive 390 dichorionic twin pregnancies (gestational age at delivery ≥24 weeks). Pregnancies complicated by in-utero fetal death or structural anomalies were excluded. Chorionicity was determined by histologic placental examination or gender. The population was subdivided into two groups. Group 1 consisted of 174 twin pairs with different gender and group 2 consisted of 216 twin pairs with same gender. Significant neonatal morbidity was defined as one or more complications including respiratory distress syndrome (RDS), bronchopulmonary dysplasia (BPD), necrotizing enterocolitis, congenital sepsis and brain lesion such as periventricular leukomalacia, intraventricular hemorrhage and cerebral infarction. We compared neonatal mortality and morbidity between two groups. Parametric and nonparametric methods were used as appropriate for statistical analysis.ResultsTwo groups showed similar gestational age at birth. Group 1 had significantly higher rates of neonatal mortality (1.7% vs. 0.2%, p <.05) and significant neonatal morbidity (9.6% vs. 5.6%, p <.05) than group 2. Even after adjustment for gestational age at birth, in vitro fertilization and discordance in birth weight (defined as 25% or more), group 1 had a significantly higher rate of neonatal morbidity than group 2 (RR, 8.58; 95% CI, 2.37-31.02, p <.01).ConclusionOur data suggests that newborns in twin pairs of different gender have adverse neonatal outcomes than those of same gender in dichorionic twins. ObjectiveThe purpose of this study was to evaluate whether neonatal outcomes are different between newborns of same gender and those of different gender in dichorionic twins. The purpose of this study was to evaluate whether neonatal outcomes are different between newborns of same gender and those of different gender in dichorionic twins. Study designWe studied consecutive 390 dichorionic twin pregnancies (gestational age at delivery ≥24 weeks). Pregnancies complicated by in-utero fetal death or structural anomalies were excluded. Chorionicity was determined by histologic placental examination or gender. The population was subdivided into two groups. Group 1 consisted of 174 twin pairs with different gender and group 2 consisted of 216 twin pairs with same gender. Significant neonatal morbidity was defined as one or more complications including respiratory distress syndrome (RDS), bronchopulmonary dysplasia (BPD), necrotizing enterocolitis, congenital sepsis and brain lesion such as periventricular leukomalacia, intraventricular hemorrhage and cerebral infarction. We compared neonatal mortality and morbidity between two groups. Parametric and nonparametric methods were used as appropriate for statistical analysis. We studied consecutive 390 dichorionic twin pregnancies (gestational age at delivery ≥24 weeks). Pregnancies complicated by in-utero fetal death or structural anomalies were excluded. Chorionicity was determined by histologic placental examination or gender. The population was subdivided into two groups. Group 1 consisted of 174 twin pairs with different gender and group 2 consisted of 216 twin pairs with same gender. Significant neonatal morbidity was defined as one or more complications including respiratory distress syndrome (RDS), bronchopulmonary dysplasia (BPD), necrotizing enterocolitis, congenital sepsis and brain lesion such as periventricular leukomalacia, intraventricular hemorrhage and cerebral infarction. We compared neonatal mortality and morbidity between two groups. Parametric and nonparametric methods were used as appropriate for statistical analysis. ResultsTwo groups showed similar gestational age at birth. Group 1 had significantly higher rates of neonatal mortality (1.7% vs. 0.2%, p <.05) and significant neonatal morbidity (9.6% vs. 5.6%, p <.05) than group 2. Even after adjustment for gestational age at birth, in vitro fertilization and discordance in birth weight (defined as 25% or more), group 1 had a significantly higher rate of neonatal morbidity than group 2 (RR, 8.58; 95% CI, 2.37-31.02, p <.01). Two groups showed similar gestational age at birth. Group 1 had significantly higher rates of neonatal mortality (1.7% vs. 0.2%, p <.05) and significant neonatal morbidity (9.6% vs. 5.6%, p <.05) than group 2. Even after adjustment for gestational age at birth, in vitro fertilization and discordance in birth weight (defined as 25% or more), group 1 had a significantly higher rate of neonatal morbidity than group 2 (RR, 8.58; 95% CI, 2.37-31.02, p <.01). ConclusionOur data suggests that newborns in twin pairs of different gender have adverse neonatal outcomes than those of same gender in dichorionic twins. Our data suggests that newborns in twin pairs of different gender have adverse neonatal outcomes than those of same gender in dichorionic twins.