263 (PB043) - A small RNA signature from extracellular vesicles in patient plasma correlates with recurrence or progression of high-grade gliomas

Abstract

Background: Glial cell-derived tumours of the central nervous system make up the largest group of brain tumours. Most are high-grade gliomas (HGG) and are universally fatal despite multimodal therapy. With a suspected HGG, surgery is undertaken for tumour de-bulking and to make a definitive diagnosis. While the tumour genetics provides some insight on prognosis, it rarely changes decision-making, nor does it predict recurrence. In managing patients with HGG, predicting recurrence, or differentiating between pseudoprogression (radiation necrosis) and true tumour progression would be invaluable in improving overall prognosis.