Abstract
Background: Inflammatory Breast Cancer (IBC) is a rare, but highly aggressive variant responsible for 10% of breast cancer related mortality. X-linked inhibitor of apoptosis protein (XIAP) can suppress immune-mediated tumor cell death by its ability to inhibit caspase activity, granzyme release, and activate NFkB and MAPK inflammatory crosstalk signaling. In this study we wanted to assess the pattern of expression of XIAP and to delineate the associated changes in the tumor immune microenvironment (TiME) for prognostic value in invasive breast cancers including inflammatory breast cancer (IBC).
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