Abstract
In vitro and in vivo studies in the rat and in man were conducted on the metabolic fate of sucrose acetate isobutyrate (SAIB). In vitro studies with rat tissues showed that SAIB was substantially hydrolysed by non-specific esterases associated with the intestinal mucosa; little hydrolysis occurred in the stomach and liver. In the intact animal, orally administered [14C]SAIB was found to be hydrolysed in the gastro-intestinal tract prior to absorption, and the subsequent fate of administered radioactivity was analogous to that of [14C]sucrose. Human studies showed that, following a single oral dose or seven daily doses of 1 g SAIB, the urine contained no sucrose or partially hydrolysed SAIB. Microflora associated with the large bowel were found to exhibit a limited capacity to hydrolyse SAIB. The results show that the use of SAIB as a food additive is unlikely to constitute a lexicological problem with respect to its metabolic fate in man.
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