Abstract
Cancer treatments such as radiotherapy can induce mitotic catastrophe, a form of cell death resulting from abnormal mitosis and leading to the formation of micronucleation and multiple nucleated cells. The mechanism of this process is not clear. In a recent study we have shown that mitotic catastrophe was a special case of chemotherapy induced apoptosis when the G2/M checkpoint is abrogated by 14–3-3 σ knock out or Chk2 inhibitor debromohymenialdisine (Oncogene 2004, 23 :4362). The aim of this study was to evaluate the mode of cell death and the implication of caspases in the cytotoxic effect of γ-irradiation (IR) on the human colorectal carcinoma HCT116 cell line (wild type or knocked out for 14–3-3σ or Chk2 genes).
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