(260) Effects of Surface Delay Agents on Penile Sensibility in Premature Ejaculation

Abstract

Abstract Introduction The penis is an important sensory organ during sexual intercourse, transforming the sensations experienced from intercourse into neural impulses and transmitting them to the central nervous system. Our previous research has found that the sensitivity of the penis varies due to histological and neuroanatomical differences between the penile shaft and glans. We have identified hypersensitivity zones within the penis, classifying them into three subtypes，namely, glans penis, penile shaft, and whole-penis hypersensitivity. However, it remains unknown whether there are differences in sensitivity after the application of surface anesthetics to these subtypes. Objective As the hypersensitivity of the penis is not uniform throughout, with specific sensitive zones, this study aims to investigate whether there are differences in sensitivity after surface delay agents are applied to the hypersensitive and hyposensitive areas. This will aid in the precise use of surface delay agents and reduce their side effects. Methods Based on the neurophysiological results, 290 patients with primary premature ejaculation were categorized into the group with single glans penis hypersensitivity, the group with single penile shaft hypersensitivity, the group with the whole penis hypersensitivity, and the group with the whole penis being hyposensitivity. Differences in sensory thresholds, latencies, and amplitudes between the hypersensitive and hyposensitive areas of the penis were compared between patients before and after the use of delaying agents on the surface of the penis. Results The surface delay agent can indiscriminately increase the sensory threshold of both the hypersensitive and hyposensitive areas of the penis (P<0.001), but it only prolongs the latency of the hypersensitive area (P<0.001), without affecting the latency of the hyposensitive area of the penis. Conclusions The effects of the surface delay agent on the hypersensitive and hyposensitive areas of the penis are different. The delay agent only extends the latency of the hypersensitive area, suggesting that there may be differences in receptors, sensory cells, and synaptic transmission of sensory nerve fibers between the hypersensitive and hyposensitive areas of the penis. Disclosure No.