Abstract
Introduction A potential impact of PGT-A on embryo implantation is often discussed in the reproduction of elderly women with a higher risk of oocyte aneuploidy while its impact is belied in women under 35 years at the same time. The authors studied the influence of PGT-A in egg donation program where the advanced reproductive age and potential oocyte incompetence is mostly excluded. Material and methods In total, 246 embryos were thawed and transferred in egg donation patients of the age category 35 plus in period January 2017 – December 2018. Group A consists of 188 patients with a comprehensive aneuploidy screening (PGT-A), group B consists of 58 patient with no PGT-A. There were performed elective single embryo transfers solely in both groups. Results In group A an implantation rate was 46% (86/188) while in group B 20%(12/58). Natural cycles with triggering ovulation were more successful than the HRT ones (IR 53% resp. 44%). Conclusions The results showed that PGT-A and transfer of euploid embryo improve an implantation rate in egg donation program in the age category 35 plus what is usually disregarded. The number of cycles to pregnancy was lower in case of a euploid embryo was transferred. The major factors involving the implantation rate besides the embryo quality and euploidy are an appropriate endometrial quality and striking the window of implantation (WOI). The implantation rate is slightly better in natural cycles compared to HRT (hormonal replacement treatment) cycles. Among other factors, we reached better results using a longer progesterone administration (minimum 5 days) and a time-lapse monitoring system used in synergy with an embryo selection for the biopsy. A potential impact of PGT-A on embryo implantation is often discussed in the reproduction of elderly women with a higher risk of oocyte aneuploidy while its impact is belied in women under 35 years at the same time. The authors studied the influence of PGT-A in egg donation program where the advanced reproductive age and potential oocyte incompetence is mostly excluded. In total, 246 embryos were thawed and transferred in egg donation patients of the age category 35 plus in period January 2017 – December 2018. Group A consists of 188 patients with a comprehensive aneuploidy screening (PGT-A), group B consists of 58 patient with no PGT-A. There were performed elective single embryo transfers solely in both groups. In group A an implantation rate was 46% (86/188) while in group B 20%(12/58). Natural cycles with triggering ovulation were more successful than the HRT ones (IR 53% resp. 44%). The results showed that PGT-A and transfer of euploid embryo improve an implantation rate in egg donation program in the age category 35 plus what is usually disregarded. The number of cycles to pregnancy was lower in case of a euploid embryo was transferred. The major factors involving the implantation rate besides the embryo quality and euploidy are an appropriate endometrial quality and striking the window of implantation (WOI). The implantation rate is slightly better in natural cycles compared to HRT (hormonal replacement treatment) cycles. Among other factors, we reached better results using a longer progesterone administration (minimum 5 days) and a time-lapse monitoring system used in synergy with an embryo selection for the biopsy.
Published Version
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