Abstract
The current study will investigate the role of NPY in the ventral hippocampus in anxiety. NPY is a neuropeptide found in many structures in the brain, including the hippocampus, and is implicated in regulation of anxiety related behaviors. The hippocampus has also been found to play a role in anxiety and defensive behaviors – specifically, the ventral hippocampus regulates innate defensive behaviors. The effect of NPY in the ventral hippocampus will be investigated by infusing either NPY (n=12) or physiological saline (n=12) into the rat ventral hippocampus followed by behavioural testing in an animal model of anxiety; i.e., the shock-probe burying task. I expect to find a selective reduction in burying duration in NPY-infused rats.
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