Abstract
This chapter discusses glyco-S-nitrosothiols (RSNO) (sugar-SNAP), a new type of nitric oxide donor. S-nitrosothiols (RSNO)—especially the low molecular weight RSNO—undergo homolytic decomposition in solution to give the disulfide and nitric oxide (NO). RSNO not only serve as valuable research tools as NO donors on the studies of the biological functions of nitric oxide but may also be used as pharmaceuticals in dealing with a variety of diseases such as hypertension, atherosclerosis, and congestive heart failure in which NO levels have declined to subphysiological levels. The issue to be addressed is the way to design NO-releasing RSNO with better pharmacokinetic properties and specificities. A series of RSNO have been synthesized, where the S-nitroso-N-acetyl penicillamine (SNAP) moiety acts as an NO donor and the sugar fragment provides the desired hydrophilicity and specificity because of intra- and inter-cellular carbohydrate-protein recognition processes. The chapter describes the general synthesis of RSNO. The chapter also discusses the synthesis of (1) glucose–1-SNAP, (2) glucose-2-SNAP, (3) glucose-6-SNAP, and (4) fructose-2-SNAP.The chapter concludes with a discussion of the stability study of sugar-SNAP.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
