26.3 Pharmacogenomic Guideline Evaluations of Psychiatric Medications and Implications for Younger Patient Populations

Abstract

Pharmacogenomic (PGx) testing has become increasingly accessible for clinical use in psychiatry. Scientific, philosophical, and practical questions about the clinical use of this information are common. Consensus guidelines by the Clinical Pharmacogenetics Implementation Consortium (CPIC) are evaluations of drug-gene pairs intended to help clinicians understand how available genetic results should be used to optimize drug therapy. The relevance of this information to younger patient populations has not been assessed directly. We will review the CPIC guideline process, evaluations of psychotropic medications, and ways that they relate to younger patient populations by highlighting selected examples of PGx studies in children and adolescents.