Abstract
25th Annual Computational Neuroscience Meeting: CNS-2016.
Highlights
We estimate parameters of the inter-spike interval distributions in binaural neurons of the mammalian sound localization neural circuit, neurons of the lateral and medial superior olive [1]
The results show that the cortical model with the abnormal structural connectivity decreased the degree of cortical response as well as the number of cortical regions responding to the input (Fig. 9), suggesting that the structural connectivity abnormality observed in APOE-4 carriers might reduce cortical information propagation and lead to negative effects in information integration
The results showed that the hemodynamic response, which corresponds to the neural activation and deactivation based on the metabolic activities of the neural tissues, are proportional to the emotional intensity and the discrepancy between the expectancy and the actuality
Summary
We estimate parameters of the inter-spike interval distributions in binaural neurons of the mammalian sound localization neural circuit, neurons of the lateral and medial superior olive [1]. Autism spectrum disorder (ASD) subjects exhibit repetitive behaviors, impaired social communication skills, and sensory problems. Those symptoms of neurodevelopmental disorder is doubted to be originated from genetic causes [2]. The aim of the research to be conducted is to reveal the genetic cause of (ASD) by the statistical analysis of network measures of ASD patients and normal groups’ structural connectome data using diffusion tensor imaging (DTI). Expected result is that there are genotypic changes of genes which affect development of neuronal connection in ASD subjects. This finding will shade a new light on the investigation of ASD diagnosis and treatment. It has been proposed that bistability in Purkinje cells play a key role in the short-term processing and storage of sensory-motor information
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