Abstract

Introduction: Adenovirus-mediated herpes simplex virus thymidine kinase gene transfer in combination with ganciclovir (Ad-TK/GCV) is one of the major gene therapy strategies to eradicate tumor cells. Leiomyoma is a benign uterine tumor that affects high percentage of women in their reproductive age. Unfortunately, there is no effective and safe medical treatment available. Leiomyom is developed as discrete well-defined tumor, easily accessible with imaging techniques which makes it a good candidate for localized gene therapy approaches.

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