25894 CLL-associated cryofibrinogenemia

Abstract

Cryofibrinogenemia is an occlusive vasculopathy characterized by cold precipitation of cryofibrinogens (CF), which may be idiopathic or secondary to malignancy, infection, or systemic inflammatory disease. Here, we present the case of a 75-year-old woman with a 1-year history of untreated chronic lymphocytic leukemia (CLL) and a new retiform purpuric eruption of the lower extremities, present for 1 month. On presentation, the patient was noted to have palpable purpuric papules and retiform purpuric patches, some of which were ulcerated centrally, on the bilateral lower legs.