2578 Promising Effect of Platelet-Rich Plasma And CO2 Laser in Urinary Incontinance

Abstract

Study Objective To evaluate the safety, feasibility and efficacy of trans-vaginal fractional micro-ablative CO2 laser therapy in combination with platelet rich plasma (PRP) for the treatment of urinary urge incontinence in women. Design Prospective observational cohort study. Setting Single private gynecology practice in Adelaide, Australia between 2013 and 2018. Patients or Participants 128 women, of whom 62 women were diagnosed with stress urinary incontinence and 66 women with urinary urge incontinence. Interventions PRP and CO2 laser were used for 3 treatments. There was 4-6 weeks interval between each treatment. Measurements and Main Results Patient outcomes were reviewed subjectively and objectively at baseline, 3 months and 12 months. The Australian Pelvic Floor Questionnaire (APFQ) and physical examination were employed to assess outcomes. • Patients with moderate to severe stress incontinence improved 63% at 12 months (p=0.001) • Patients with moderate to severe urge incontinence improved 55% at 12 months (p=0.003) Conclusion PRP and vaginal laser appear to be promising alternative treatments for urinary incontinence with potential reduction in cost to both the patient and national health systems without any complications or side-effects. However, the true efficacy of these modalities need to be examined in an RCT setting.