Abstract
With demonstration of effective therapies for advanced cSCC, and as immunotherapy in the adjuvant setting is being considered, accurate prognosis is critical. A prognostic 40-gene expression profile (40-GEP) test was recently validated using an independent cohort of cSCC patients with ≥1 risk factors to accurately classify patients as low (Class 1), moderate (Class 2A), or high risk (Class 2B) for metastasis. Ongoing prospective clinical validation and utility studies are discussed. This analysis evaluated impact of 40-GEP risk stratification as enrollment criteria into adjuvant therapy trial design.
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