Abstract
The antioxidant activities and superoxide dismutase (SOD)-like effects of agrimonolide and desmethylagrimonolid from Agrimonia pilosa Ledeb were investigated. The exposure of HepG2 cells to agrimonolide or desmethylagrimonolide will improve the expression of heme oxygenase-1 (HO-1). Agrimonolide and desmethylagrimonolid effectively attenuated H 2 O 2 -induced cell damage. The mechanisms underlying this protective effect include: (1) free radicals scavenging activities, (2) activation of Nrf2-driven pathways; (3) inhibition of p38 phosphorylation (4) activation of ERK, JNK, and MAPK phosphorylation; (5) elevation of the activity of antioxidative enzymes SOD; (6) increased expression of HO-1. In conclusion, our results indicated that transcriptional activation of Nrf2/ARE is critical in agrimonolide and desmethylagrimonolide-mediated HO-1 induction, which can be regulated in part by the blockade of p38 MAPK signaling pathway and inhibiting nuclear translocation of Nrf2.
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