256 PRENATAL TESTOSTERONE AND MIDLINE CYST OF THE PROSTATE: THE RELATIONSHIP BETWEEN 2D:4D DIGIT RATIO AND MIDLINE CYST IN BPH PATIENTS AND HEALTHY YOUNG VOLUNTEERS

Abstract

You have accessJournal of UrologyPediatrics: Basic Research1 Apr 2011256 PRENATAL TESTOSTERONE AND MIDLINE CYST OF THE PROSTATE: THE RELATIONSHIP BETWEEN 2D:4D DIGIT RATIO AND MIDLINE CYST IN BPH PATIENTS AND HEALTHY YOUNG VOLUNTEERS Seiji Furuya, Shin-ichi Hisasue, Haruaki Kato, and Syogo Shimamura Seiji FuruyaSeiji Furuya Kitami, Japan More articles by this author , Shin-ichi HisasueShin-ichi Hisasue Sapporo, Japan More articles by this author , Haruaki KatoHaruaki Kato Matsumoto, Japan More articles by this author , and Syogo ShimamuraSyogo Shimamura Sapporo, Japan More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2011.02.347AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Midline cyst of the prostate (MLC) is incidentally found in 5–10% of adult males. We previously reported that most case of MLC is cystic dilation of the utricle in the transrectal ultrasound-guided opacification and dye-injection study. It is believed that prenatal androgen deficiency is the key in the utricular enlargement. The 2nd to 4th finger length ratio (2D:4D) are sexually dimorphic and the higher 2D:4D in male indicates decreased prenatal androgen exposure. The aim of this study is to clarify the relationship between MLC and 2D:4D digit ratio. METHODS This study included 118 BPH patients and 61 healthy male college students. All MLCs were identified by the transrectal ultrasonography. In the BPH group, 57 MLC (+) men (mean age 65.4 years) and age-matched 61 MLC (−) men (mean age 66.4 years) were included. In the college student group, 12 MLC (+) men (mean age 23.0 years) and age-matched 49 MLC (−) men (mean age 22.8 years) were included. There were no other urological disorders, including hypospadias and cryptorchidism. We took the photocopies of bilateral hands of the participants, and measured the 2nd and 4th finger length by one examiner with a blind manner. RESULTS 2D:4D digit ratios in BPH group (right/left Mean±SD) were higher bilaterally in MLC (+) (0.95±0.03/0.95±0.03) than those in MLC (−) (0.92±0.03/0.92±0.03; p<0.0001/p<0.0001). 2D:4D in students were higher bilaterally in MLC (+) (0.96±0.03/0.94±0.03) than those in MLC(−) (0.93±0.03/0.94±0.03; p=0.0018/p=0.0001). CONCLUSIONS Prostatic utricle is considered to originate from urogenital sinus and/or Mulerian duct embryologically. Androgen receptors are distributed in urogenital sinus, and it is believed that a testosterone deficiency leads to utricular enlargement and/or hypospadias. In the current study, 2D:4D of MLC (+) men was significantly higher than that in MLC (−) men. We conclude that decreased prenatal androgen exposure led to utricular enlargement and midline cyst as a remnant of prostatic utricle. © 2011 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 185Issue 4SApril 2011Page: e103 Advertisement Copyright & Permissions© 2011 by American Urological Association Education and Research, Inc.MetricsAuthor Information Seiji Furuya Kitami, Japan More articles by this author Shin-ichi Hisasue Sapporo, Japan More articles by this author Haruaki Kato Matsumoto, Japan More articles by this author Syogo Shimamura Sapporo, Japan More articles by this author Expand All Advertisement Advertisement PDF DownloadLoading ...