Abstract
Vitamin C has been shown in both in vitro and animal studies to prevent oxidative damage to keratinocytes, suggesting a putative role in the chemoprevention of keratinocyte carcinomas, including cutaneous squamous cell carcinoma (cSCC). However, epidemiologic studies examining the association between vitamin C and subsequent cSCC risk have shown conflicting results. We investigated the association between self-reported vitamin C intake and cSCC risk in 67,773 non-Hispanic whites from the Kaiser Permanente Genetic Epidemiology Research on Adult Health and Aging (GERA) cohort using multivariable logistic regression models adjusting for age, sex, body mass index, and smoking status.
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