Abstract
Background: Long lifetime exposure to elevated estrogen levels is associated with a higher risk for developing estrogen receptor-positive (ER+) breast cancer in postmenopausal women. A factor that can influence estrogen levels is the intestinal bacterial enzyme β-glucuronidase (GUS), which can de-conjugate estrogens, leading to their reabsorption into the circulation. In this pilot study, we aimed to investigate if there was a significant difference in fecal GUS activity between postmenopausal ER+ breast cancer patients and postmenopausal controls.
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