Abstract
253: Expression of TRF2 and its prognostic relevance in advanced stage cervical cancer patients
Highlights
Telomeres are protective caps consisted of specific tandem repeats (5′-TTAGGG-3′)
The cap structure of telomeres is preserved by shelterin complex consisted of six proteins, telomere repeat-binding factors 1 and 2 (TRF1, TRF2), protection of telomeres protein 1 (POT1), heterodimeric partner of POT1 known as TPP1, TRF1-interacting nuclear factor
TRF2 expression was determined in cervical cancer patients admitted to the Dr Lutfi Kirdar Kartal Training and Research Hospital Radiation Oncology Department
Summary
Telomeres are protective caps consisted of specific tandem repeats (5′-TTAGGG-3′). Shortening of telomeres at each cell division is known as “mitotic clock” of the cells, which renders telomeres as important regulators of lifespan. TRF2 is one of the critical members of shelterin complex, which is a protein complex responsible from the preservation of cap structure, and loss or mutation of TRF2 results in DNA damage, senescence or apoptosis. Since cancer is frequently associated with aberrant cell cycle progression, defective DNA repair or apoptosis pathways, TRF2 could be one likely candidate for cancer therapy. The cap structure of telomeres is preserved by shelterin complex consisted of six proteins, telomere repeat-binding factors 1 and 2 (TRF1, TRF2), protection of telomeres protein 1 (POT1), heterodimeric partner of POT1 known as TPP1, TRF1-interacting nuclear factor. Since cancer is frequently associated with aberrant cell cycle progression, defective DNA repair or apoptotic pathways, TRF2 could be one likely candidate for cancer therapy
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
