252. Clinical Outcomes and Risk Factor of Severe Disease in Young Adult Patients Compared with Middle-Aged Patients Who Infected with COVID-19: A Large Cohort Study in Tertiary Hospital

Abstract

Abstract Background Coronavirus disease 2019 (COVID-19) is increasing rapidly among young adults in worldwide. Our knowledge, COVID-19 was more severe in elderly patients. Only few studies described clinical and outcome of young adults with COVID-19 infection. A recent large retrospective data in US found increasing severity of COVID-19 in young adults due to obesity, hypertension, and diabetes, however there is lacking Asian ethnicity in this study. We aimed to evaluate clinical outcome of COVID-19 infection in young adult and middle-aged group. Methods A cohort study was carried out in 10,072 patients with confirmed COVID-19 infection were admitted to Hatyai hospital, Songkhla, Thailand from 1 April 2021 to 31 December 2021. We collected data directly from patient and medical record. The results of primary objective were compared young adults and middle-aged patients and secondary objective were analyzed risk factor of severe COVID-19 among young adult patients by multivariable logistic regression analysis. Results The preexisting disorders were significant more observed in middle-aged group. Obesity was the most common in both group, 540 [(11.66%) and 800 (14.17%) patients; p< 0.001] in young adult and middle-aged group respectively. Diabetes and hypertension were frequently observed in middle-aged group. Severe pneumonia was found [500 (9.19%) compared with 99 (2.14%); (adjusted odd ratios (aORs) 2.75; 95% confident interval (CI) 2.18 – 3.49) p< 0.001] patients in middle-aged group and young adult group. mortality rate was more in middle-aged group [91 (1.67%) and 11 patients (0.24%); [aORs 4.08 (95%CI 2.12 – 7.87) p< 0.001]. The risk of severe pneumonia among young adults group. Diabetes was the most increased risk (9 (9.09%) patients in severe pneumonia [aOR 16.27 (95%CI 5.82 – 45.5; p-value< 0.001)]. Conclusion Data from our study was different than another. In US or Europe young adult was increased severity of COVID-19 due to their pre-existing disease (obesity, diabetes, and hypertension). But in Asian population co-morbidity not much as in US or Europe therefore middle-aged group still had more severe COVID-19 than young adults. The factor contributing to the severe COVID-19 among young adult group, diabetes was the most common and followed by cardiovascular disease and HIV infection. Disclosures All Authors: No reported disclosures.