251-OR: Maternal Diabetes during Pregnancy and Incidence of Depression and Anxiety in Offspring from Childhood to Young Adulthood

Abstract

Many mental health disorders have roots in childhood; diabetes during pregnancy may play a role. We assessed risks of depression and anxiety in offspring associated with maternal pre-existing type 1 (T1D) , type 2 (T2D) , and gestational diabetes (GDM) with and without antidiabetic medications during pregnancy. The cohort included 439,590 singletons born in 1995-2015; followed up to Dec. 2020. Mother’s diabetes status during pregnancy, covariates, and child’s first clinical diagnosis of depression and/or anxiety since age 5 were obtained from electronic medical records. Cox regression was used to assess the associations for all ages and separately for ages 5-12, >12 to 18, and >18 to 26 years. During follow-up, 6.8% of offspring had a clinical diagnosis of depression and 13.4% had a diagnosis of anxiety. Figure 1 shows cumulative incidence of depression and anxiety by maternal diabetes exposure and covariate adjusted hazard ratios for diabetes types relative to unexposed. T1D, T2D, GDM requiring medications were all significantly associated with depression and anxiety in offspring (p<0.for all) ; whereas GDM without medications was not (p>0.5) . The significant associations were observed for ages 5-12 and >12-18 years. These data suggest that severity of diabetes during pregnancy may increase offspring’s vulnerability for depression/anxiety during childhood and adolescence. Disclosure A.Xiang: None. S.A.Carter: None. J.C.Lin: None. T.Chow: None. M.P.Martinez: None. J.M.Alves: None. K.A.Page: None. R.Mcconnell: None. S.Negriff: None.