#2513 EFFECT OF HEMODIALYSIS WITH MEDIUM CUT-OFF VERSUS HIGH-FLUX MEMBRANES ON ENDOTHELIAL FUNCTION OF CHRONIC KIDNEY DISEASE PATIENTS

Abstract

Abstract Background and Aims Endothelial dysfunction (ED) is considered a marker of vascular complications, especially in patients with chronic kidney disease (CKD). Inflammation and the uremic state contribute to ED in hemodialysis (HD) patients. Recently, the medium cut-off (MCO) HD membrane has been proposed to efficiently remove inflammatory cytokines and higher molecular weight uremic toxins. This study aimed to compare the effect of dialysis with medium cut-off (MCO) or high-flow (HF) membranes on the endothelial function of patients on chronic HD. Method A prospective, randomized, crossover study in which 32 patients with CKD were dialyzed for 12 weeks with each membrane, including a 4-week washout period between treatments. Endothelial function was assessed by flow-mediated dilation (FMD) using brachial artery ultrasound at weeks 1, 12, 16, and 28. Results The population consisted of 59% men, 52.7±13.4 years, 16% non-black, on HD for 8.8(4.1-15.1) years, 72% with arteriovenous fistula). Hypertension was the most common etiology of CKD and 34% of patients had previous cardiovascular disease. Table 1 shows clinical and demographic characteristics of all subjects. The Patients were grouped, regardless of treatment sequence, into MCO or high flow groups, since no drag (p = 0.634) or sequence (p = 0.998) effects were observed in the FMD assessment. The ANOVA model with repeated measures showed no effects of treatment (p = 0.426), time (p = 0.972) or interaction (p = 0.413) in the comparison of FMD, between the MCO and high flow groups. Conclusion Dialysis performed with MCO, or HF membranes did not influence endothelial function in patients undergoing chronic HD.