251 (PB-075) Poster - Plasma L-arginine metabolic profiling in breast cancer patients reflects differences in cellular gene expression and metabolic activities according to subtype – A translational study in human breast cancer

Abstract

Background: L-arginine is a semi-essential amino acid; its availability for protein synthesis is limiting for cell proliferation. It is also a substrate for nitric oxide synthases (nNOS, iNOS, eNOS) and arginases (ARG) 1 and 2. The effects of L-arginine on cell proliferation and disease progression in breast cancer have remained controversial. We studied whether breast cancer subtypes show different levels of L-arginine and its metabolites, and if this relates to NOS and ARG isoform expression and tumor cell proliferation.