Abstract
The aim of this study was to investigate the expression of Insulin like Growth Factor-I receptor (IGF-Ir) and Transforming Growth Factor-alpha (TGF-α) in 42 effusion smears, using an immunocytochemical technique. We have studied 18 peritoneal and 24 pleural effusion smears from patients with endometrial (5), ovarian (7), colorectal (3), liver (3), breast (14) and lung (10) carcinomas. Fifteen effusion smears from patient with benign diseases were used as control group. IGF-Ir immunoreactivity was detected in 15/24 (62.5%; of pentoneal and 14/24 (58.3%) of pleural effusion smears. TGF-α immunoreactivity was observed in 12/18 (66.7%) of peritoneal and 10/18 of pleural effusion smears. Benign effusion smears were found to be negative for IGF-Ir and TGF-α immunoreactivity. These results suggest that the expression of IGF-Ir and TGF-α In malignant effusion smears plays an important role for the prediction of biologically high malignant potential
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