25031 Greater disease burden associated with palmoplantar pustulosis versus plaque psoriasis: Real-world evidence from the North American–based Corrona Psoriasis Registry

Abstract

Palmoplantar pustulosis (PPP) is a subtype of psoriasis, localized to the palms and soles. Relatively little is known about the natural history of PPP. Given the paucity of available information, this descriptive study outlines the characteristics, clinical outcomes, and patient-reported outcomes (PROs) of patients with PPP versus those with plaque psoriasis. Enrollment data from the Corrona Psoriasis Registry (a prospective, multicenter registry for patients with psoriasis) were analyzed, comparing patients with PPP (n = 64) and plaque psoriasis (n = 4894). Data include sociodemographics, disease characteristics, PROs, and medication use. There are notable differences between patients with PPP and plaque psoriasis. Although patients with PPP had a smaller median (p25, p75) percentage body surface area (BSA) affected (3 [1, 5.5] vs 5 [1, 12]), when assessing median (p25, p75) visual analog scores (range 0-100), they had greater itch (40 [15, 76] vs 22 [5, 70]), higher fatigue (35 [10, 60] vs 20 [4, 50]), and more pain (35 [5, 63] vs 5 [0, 35]) than patients with plaque psoriasis. Importantly, median reported percentage of impairment while working (10 [0, 53] vs 0 [0, 15]) and in daily activities (30 [5, 50] vs 3 [0, 25]) was greater for patients with PPP. Despite affecting a smaller BSA than plaque psoriasis, the presence of pustules on the palms and soles among patients with PPP has a distinct impact on patient wellbeing, with greater itch, fatigue, and pain reported. These translate into a considerable impairment in both work and daily activities.