25009 Manager of technology

Abstract

The purpose of this study is to demonstrate the benefit of the self foaming technology with methyl perfluorobutyl/perfluoroisobutyl ether in a commercial foaming facial cleanser (FFC) in generating finer bubbles, and more effectively preventing skin lipid peroxidation and removing skin damaging lipid peroxidation byproducts. In vitro pig skin has been successfully used recently to predict antipollution skin benefit in vivo (Bielsfeldt, 2018). Using a novel method we developed recently, pig skin was exposed to ozone to generate lipid peroxides in a well-controlled manner. It was then quantified using a lipid peroxidation (LPO) assay kit. The assay uses the colorimetric reaction between thiobarbituric acid (TBA) and malondialdehyde (MDA) to measure the degree of oxidation. MDA is a secondary byproduct of lipid peroxidation and is commonly used as a biomarker for skin lipid oxidation. Results showed that the facial cleanser formula with self foaming technology generated much finer bubbles and was more effective in removing free radical byproduct and preventing skin lipid from oxidation vs the placebo formula without the self foaming technology, offering antipollution benefits.