Abstract
In human foreskin fibroblast (HF) cultures, two proteins with Mr 60,000 and 55,000 were found to be induced about 3.5−fold by EGF, PDGF and β−TGF. The induced proteins were identified as procollagenases by immunoprecipitation of induced medium with antibodies to purified human fibroblast collagenase. Collagenase enzyme activity in the medium from EGF-treated cultures was also induced at least 3-fold compared to control cultures. Induction of collagenase was dependent upon de novo protein and RNA synthesis and was observed in the medium 10 hours after addition of EGF. Although they interact with separate membrane receptors, these three growth factors induce the secretion of a common protein. As a result, our study suggests that collagenase may be an important mediator of cell mobilization, a process which is essential for mito-genesis.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
