25 hydroxyvitamin D and nutritional parameters correlation in adults with stage 4 chronic kidney disease

Abstract

Serum concentrations of 25-hydroxyvitamin D (abbreviated "25(OH)D") and parameters of nutritional status both decline as chronic kidney disease (CKD) progresses. The objective of this study was to measure and correlate 25(OH)D concentrations with alterations in the nutritional status of adult patients with stage 4 CKD. The study was cross-sectional, included patients with stage 4 CKD (CKD-Epi between 15 and 30ml/min/1.73m2), between the ages of 18 and 65, who sought services at the Department of Nephrology between April 2016 and April 2017. seventy participants were evaluated; the median age was 47 years old (interquartile range [IQR] of 33-53 years), and 54% of the participants were women. All of the participants presented 25(OH)D serum concentrations below 30ng/ml. According to a Subjective Global Assessment, 32.6% of the study population was malnourished and 14% presented protein energy wasting. An inverse and proportional correlation was found between levels of 25(OH)D and urea (r=-0.342), cholesterol (r=-0.383), triglycerides (r=-0.316), and extracellular water (r=-0.399). In contrast, levels of 25(OH)D were directly proportional with serum albumin (r=0.388), serum hemoglobin (r=0.331), phase angle (r=0.355), resistance (r=0.518), and reactance (r=0.580) in a statistically significant manner (p<0.05). All the participants in this study presented levels of 25(OH)D considered to be deficient. Levels of 25(OH)D were shown to be significantly correlated with alterations in nutritional status. It is necessary to implement effective interventions to help correct these deficiencies in patients with CKD.