Abstract
In vitro incubation of 3H-25-hydroxycholecalciferol with 105,000 x g supernatants from homogenates of rachitic rat kidney and skeletal muscle resulted in sedimentation of radioactivity at 5–6 S, in contrast to the 3–4 S sedimentation observed when the sterol was incubated with rachitic serum. The binding of 3H-25-hydroxycholecalciferol by these tissue extracts was reduced by exposure to anti-rachitic sterols containing an open B ring with C 10 methylene and C 9 hydrogenation, and by pre-incubation of the extracts with trypsin.
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