25 Epoetin Alfa and Darbepoetin Alfa Costs by Dominant Dosing Interval in Chronic Kidney Disease Not on Dialysis

Abstract

26 PERCUTANEOUS KIDNEY BIOPSIES IN A SOUTHEASTERN TEACHING HOSPITAL: INDICATIONS, BIOCHEMICAL PROFILES, AND RECOVERED HISTOLOGICAL DIAGNOSES. Justin Bain, David Pruett, Lajos Zsom, Albert Dreisbach, T. Fulop. University of Mississippi Medical Center, Jackson, MS. Indications for procedures may evolve over time and display a regional pattern of variation as well. We sought to review our current experience with percutaneous kidney biopsy (PKB) in our institution. We have performed a retrospective data review of PKB obtained via renal trainees over a 3-year period (01/2007 12/2009) at the University of Mississippi Medical Center. We collected information on baseline parameters, underlying diagnoses, PKB indications and the recovered diagnoses. Data was analyzed with PAWS Statistics 18 and results expressed as either percents (%) or means with standard deviation (SD). The study was reviewed and approved by the University of Mississippi Human Research Office. Results from 70 PKB (71.4% native, 24.3% deceased donor) were analyzed; main indications for biopsy were impaired renal function in 37 (52.9%) and proteinuria in 33 (47.1%) patients. Baseline Blood Urea Nitrogen was 38 (29.8) mg/dL, creatinine 3.15 (3.09) mg/dL, and random urine protein/creatinine (UPC) ratio 5.85 (7.27). Mean platelet count was 274,770 (101,301)/mm3, PT 10.4 (1.1) sec, PTT 25.9 (3.1) sec. Major recovered histological diagnoses included lupus nephritis (23.5%), focal sclerosis (20.6%), chronic scarring (20.6%), acute tubular necrosis (11.8%), diabetes (7.4%), acute cellular or humoral rejection (7.4%) and membranous nephropathy (4.4%). Diabetes and lupus on biopsy correlated closely with proceeding history (r 0.580 and 0.847; p<0.001 for both). Only 3 specimens returned with “No diagnostic changes”. Thus, in this Southeast cohort of patients, indications for PKB remained vigorous and a large array of significant diagnoses were recovered. 27