Abstract
Chondroid differentiation in squamous cell carcinoma (SCC) is extremely rare. Two such cases in oesophagus have been previously reported in the literature.1,2 We present a case of an 81-year-old man who presented with an 8 mm nodule in the forehead. Microscopy reveals a SCC showing extensive areas of chondroid differentiation and some areas of sebaceous differentiation. The superficial squamous epithelium shows an intraepidemal SCC. An area of perineural invasion is present. The epithelial component is positive for p63 and 34betaE12 and negative for EMA and Ber-Ep4 while chondroid component is positive for S100. Chondroid differentiation in squamous cell carcinoma (SCC) is extremely rare. Two such cases in oesophagus have been previously reported in the literature.1,2 We present a case of an 81-year-old man who presented with an 8 mm nodule in the forehead. Microscopy reveals a SCC showing extensive areas of chondroid differentiation and some areas of sebaceous differentiation. The superficial squamous epithelium shows an intraepidemal SCC. An area of perineural invasion is present. The epithelial component is positive for p63 and 34betaE12 and negative for EMA and Ber-Ep4 while chondroid component is positive for S100.
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