24-hour average heart rate in patients with insulin resistance

Abstract

Studies have demostrated an increase in cardiovascular risk related with heart rate(HR)>80 bpm. An association between HR and other risk factors has been found, including the components of the metabolic syndrome(MS), and both could be reflective of an activation of the sympathetic nervous system(SNS). 1.To correlate mean HR with Insulin resistance(IR), and MS. 2.To verify if the increase in HR correlates in an independent way with C-reactive protein(CRP)as an inflammatory marker. N=190;98M,aged 35–85(58+-12),110 hypertensives,93 DM2, 65 dyslipemics,28 smokers.BMI(Kg/m2), waist(cm), Glycaemia, Triglycerides, Chol, HDLc HITACHI, LDL:Friedewald, Insulinaemia (μU/mL) Inmmulite DPC, C-peptide(ng/mL) Inmulite 2000 and IR(HOMA score).CRP(mg/l):Nephelometer. Hemodynamic parameters:ABPM:Spacelabs Model 90207.Average Systolic,Diastolic and Mean BP, Ambulatory Pulse Pressure(PP),HR. Statistical analysis: t-Student, Chi-square,multivariate analysis. 1.A total of 44.2% of patients had a Mean HR>75 bpm.They were younger(p=0.008) and had a greater waist circumference(p=0.001), IR(p=0.007), insulinaemia(p=0,016), C-peptide (p=0.001) and triglyceridemia(p=0,004). There were no differences in relation to BMI, glycaemia, chol, LDL and HDL. 2.Patients with a higher average HR had greater average Systolic BP(p=0,023), Diastolic BP(p<0,001), Mean BP(p<0,001) and PP(p=0,012). 3.CRP was higher in patients with elevated HR(p<0,05). 1.Average HR>75 bpm is correlated with waist circumference, IR, insulinaemia, C-peptide and triglyceridemia. 2.In spite of being of younger, patients with a higher average HR had greater Systolic BP, Diastolic BP, Mean BP and PP. 3.CRP was higher in patients with greater HR,but not in an independent way. 4.Activated SNS could participate in the genesis of the MS and its complications. 5.Average HR could be a reliable marker of this activation and its consequences.